Signal library
A library of all the signals published in the WHO Pharmaceuticals Newsletter since 2012.
More information could emerge after publication which might alter the conclusion in the assessments. For more information on signals, please see "General information on signals in the WHO Pharmaceuticals Newsletter", "What is a signal?" and Signal detection at UMC.
For more information on issues relating to the tentative nature of data underlying signals and to data protection matters please read the UMC caveat document.
For details on the UMC measures of disproportionate reporting please read Disproportionate Reporting.
123 documents found.
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Signals
Acenocoumarol and semaglutide – Drug interaction
WHO Pharmaceuticals Newsletter, June 2022 (No. 2), p16-20.
Author: Uppsala Monitoring Centre
Date: 2022-06-29 -
Signals
Covid-19 vaccines and hearing loss and tinnitus
WHO Pharmaceuticals Newsletter, January 2022 (No. 1), p18-30.
Author: Christian Rausch and Qun-Ying Yue
Date: 2022-01-31 -
Signals
Methotrexate and muscle spasm
WHO Pharmaceuticals Newsletter, January 2022 (No.1), p31-34.
Author: Rosa María Papale & Mónica Tarapués
Date: 2022-01-31 -
Signals
Tocilizumab and gastric perforation
WHO Pharmaceuticals Newsletter, January 2022 (No.1), p35-40.
Author: Qun-Ying Yue & Dr Elenor Kaminsky
Date: 2022-01-31 -
Signals
Amiodarone and rivaroxaban and gastrointestinal haemorrhage
WHO Pharmaceuticals Newsletter, No.4, 2021, p13
Author: Annette Rudolph
Date: 2021-08-23 -
Signals
Levetiracetam and Hypokalaemia
WHO Pharmaceuticals Newsletter, 2021, No.3, p12.
Author: Mónica Tarapués
Date: 2021-07-13 -
Signals
Sarilumab, tocilizumab - Pneumothorax
WHO Pharmaceuticals Newsletter, 2021, No.1, p14.
Author: Rebecca E Chandler
Date: 2021-05-27 -
Signals
Repeated capsaicin exposure leading to severe and possibly chronic hypersensitivity
WHO Pharmaceuticals Newsletter, 2021, No.1, p11.
Author: Marian Attalla and Lovisa Sandberg
Date: 2021-05-27 -
Signals
Tramadol and Hyponatraemia – new aspects of an old signal
WHO Pharmaceuticals Newsletter, 2021, No.1, p25.
Author: Sara Hult
Date: 2021-03-04 -
Signals
Dronedarone-induced hyperkalemia
WHO Pharmaceuticals Newsletter, 2020, No.6, p12.
Author: Dr Qun-Ying Yue, Uppsala Monitoring Centre
Date: 2021-01-04 -
Signals
Aciclovir or valaciclovir - Acute generalised exanthematous pustulosis
WHO Pharmaceuticals Newsletter, 2020, No.4, p11.
Author: Camilla Westerberg
Date: 2020-09-15 -
Signals
Clozapine – Drug dose titration not performed
WHO Pharmaceuticals Newsletter, 2020, No.3, p11.
Author: Alem Zekarias
Date: 2020-08-10 -
Signals
Agomelatine and Increased Blood Pressure
WHO Pharmaceuticals Newsletter, 2020, No.2, p14.
Author: Dr. Tamás Paál
Date: 2020-05-25 -
Signals
Colecalciferol and insomnia
WHO Pharmaceuticals Newsletter, 2020, No.1, p11.
Author: Anna Hegerius
Date: 2020-03-10 -
Signals
Levonorgestrel-releasing intrauterine device and panic attacks
WHO Pharmaceuticals Newsletter, 2019, No.6, p12.
Author: Elki Sollenbring
Date: 2020-01-20 -
Signals
Nintedanib and ischaemic colitis
WHO Pharmaceuticals Newsletter, 2019, No.6, p18.
Author: Rebecca E Chandler
Date: 2020-01-20 -
SignalsLevonorgestrel-releasing intrauterine system products and suppressed lactation
WHO Pharmaceuticals Newsletter, 2019, No.5, p16.
Author: Marielle Lavallee
Date: 2019-11-01 -
Signals
Vortioxetine and aggression
WHO Pharmaceuticals Newsletter, 2019, No.5, p19.
Author: Corine Ekhart
Date: 2019-11-01 -
Signals
Methylphenidate and lockjaw
WHO Pharmaceuticals Newsletter, 2019, No.4, p18.
Author: Marian Attalla
Date: 2019-08-01 -
Signals
Combination products containing guaifenesin, paracetamol, and phenylephrine reported with severe upper abdominal pain
WHO Pharmaceuticals Newsletter, 2019, No.4, p14.
Author: Dr Kristina Star
Date: 2019-08-01 -
Signals
Factor Xa inhibitors and haematospermia
WHO Pharmaceuticals Newsletter, 2019, No.3, p15.
Author: Kim Alting
Date: 2019-07-01 -
Signals
Desloratadine and the risk of experiencing dry eyes
WHO Pharmaceuticals Newsletter, 2019, No.3, p11.
Author: Sarah Watson
Date: 2019-07-01 -
Signals
Etanercept and ophthalmic herpes
WHO Pharmaceuticals Newsletter, 2019, No.3, p13.
Author: Sarah Watson
Date: 2019-07-01 -
Signals
Esomeprazole and gynaecomastia in obese adults
WHO Pharmaceuticals Newsletter, 2019, No.2, p14.
Author: Dr Anthony Wong
Date: 2019-06-13 -
Signals
Glibenclamide/glyburide and palpitations in the Asian population
WHO Pharmaceuticals Newsletter, 2019, No.2, p17.
Author: Raquel Herrera Comoglio
Date: 2019-06-13 -
Signals
Selegiline and hypoglycaemia in underweight adults
WHO Pharmaceuticals Newsletter, 2019, No.2, p23.
Author: Dr Richard Hill
Date: 2019-06-13 -
Signals
Levofloxacin and myoclonus in the elderly over 75 years: susceptibilities and prescribing issues
WHO Pharmaceuticals Newsletter, 2019, No.1, p12.
Author: Sofia Zappacosta, Dr Ruth Savage
Date: 2019-03-19 -
Signals
Methotrexate – Incorrect drug administration rate
WHO Pharmaceuticals Newsletter, 2019, No.1, p18.
Author: Marian Attalla
Date: 2019-03-19 -
Signals
Omalizumab and anaphylactic shock in females
WHO Pharmaceuticals Newsletter, 2019, No.1, p19.
Author: Dr Mauro Venegoni
Date: 2019-03-19 -
Signals
Aflibercept - Deep vein thrombosis/pulmonary embolism
WHO Pharmaceuticals Newsletter, 2018, No.6, p12.
Author: Rebbeca Chandler, Yasunori Aoki, Lovisa Sandberg,
Date: 2018-12-01 -
Signals
Brivudine and 5-fluorouracil – Persistence of a fatal drug-drug interaction
WHO Pharmaceuticals Newsletter, 2018, No.6, p20.
Author: Raghu Damarla, Rebecca Chandler
Date: 2018-12-01 -
Signals
Ceftriaxone - Hepatitis in patients 75 years and older
WHO Pharmaceuticals Newsletter, 2018, No.6, p24.
Author: Ian Boyd
Date: 2018-12-01 -
SignalsDesogestrel and severe psychiatric disorders: panic attack, suicidal ideation and self-injurious behaviour
WHO Pharmaceuticals Newsletter, 2018, No.5, p13.
Author: Sarah Watson
Date: 2018-11-01 -
Signals
Edoxaban – Incorrect dose administered
WHO Pharmaceuticals Newsletter, 2018, No.5, p16.
Author: Alem Zekarias
Date: 2018-11-01 -
Signals
Metamizole – Documented hypersensitivity to administered product
WHO Pharmaceuticals Newsletter, 2018, No.5, p17.
Author: Alem Zekarias
Date: 2018-11-01 -
Signals
Inconsistent labelling for drug interactions
WHO Pharmaceuticals Newsletter, 2018, No.4, p16.
Author: Sofia Zappacosta, Sarah Watson, Marian Attalla
Date: 2018-08-28 -
Signals
Agomelatine – Inappropriate schedule of drug administration
WHO Pharmaceuticals Newsletter, 2018, No.4, p15.
Author: Alem Zekarias
Date: 2018-08-28 -
Signals
Vemurafenib - Cardiac failure
WHO Pharmaceuticals Newsletter, 2018, No.3, p14.
Author: Ian Boyd
Date: 2018-06-01 -
Signals
Rosuvastatin and ticagrelor - Rhabdomyolysis
WHO Pharmaceuticals Newsletter, 2018, No.3, p10.
Author: Viola Macolić Šarinić
Date: 2018-06-01 -
Signals
Quetiapine - Valproic acid interactions
WHO Pharmaceuticals Newsletter, 2018, No.2, p19.
Author: Daniele Sartori
Date: 2018-04-01 -
Signals
Artemether/Lumefantrine - Stevens-Johnson syndrome:
WHO Pharmaceuticals Newsletter, 2018, No.2, p14.
Author: Birgitta Grundmark
Date: 2018-04-01 -
Signals
Ciprofloxacin, enalapril - Acute kidney injury: strengthening of a drug interaction signal
WHO Pharmaceuticals Newsletter, 2018, No.1, p16.
Author: Ruth Savage
Date: 2018-02-01 -
Signals
Ivermectin - Serious neurological events
WHO Pharmaceuticals Newsletter, 2018, No.1, p21.
Author: Rebecca Chandler
Date: 2018-02-01 -
Signals
Dabigatran – Thromboembolism
WHO Pharmaceuticals Newsletter, 2016, No.3, p15.
Author: Marilina Castellano, Daniele Sartori, Ruth Savage
Date: 2017-11-24 -
Signals
Amitriptyline - Dry eyes
WHO Pharmaceuticals Newsletter, 2017, No.5, p14.
Author: Henric Taavola
Date: 2017-10-01 -
Signals
Systemic hormonal contraceptive - Complete loss of female libido
WHO Pharmaceuticals Newsletter, 2017, No.5, p15.
Author: Sarah Watson
Date: 2017-10-01 -
Signals
Desloratadine/Loratadine - Weight increase
WHO Pharmaceuticals Newsletter, 2017, No.4, p15.
Author: Ermelinda Viola, , Anita Conforti,
Date: 2017-08-01 -
Signals
Ruxolitinib - Peripheral neuropathy
WHO Pharmaceuticals Newsletter, 2017, No.4, p19.
Author: Thomas Bradley
Date: 2017-08-01 -
Signals
Pregabalin - Visual colour distortions
WHO Pharmaceuticals Newsletter, 2017, No.3, p19.
Author: Linda Härmark
Date: 2017-06-01 -
Signals
SGLT-2 inhibitors - Genital pruritus
WHO Pharmaceuticals Newsletter, 2017, No.3, p23.
Author: Rebecca Chandler
Date: 2017-06-01 -
Signals
Ibrutinib - Pneumonitis
WHO Pharmaceuticals Newsletter, 2017, No.3, p14.
Author: Birgitta Grundmark
Date: 2017-06-01 -
Signals
Levothyroxine - Panic Attacks
WHO Pharmaceuticals Newsletter, 2017, No.2, p23.
Author: Niklas Norén, Birgitta Grundmark
Date: 2017-04-01 -
Signals
Idelalisib - Leukoencephalopathy
WHO Pharmaceuticals Newsletter, 2017, No.2, p17.
Author: Rebecca Chandler
Date: 2017-04-01 -
Signals
Chymotrypsin – Anaphylactic shock
WHO Pharmaceuticals Newsletter, 2017, No.1, p17.
Author: Birgitta Grundmark, Ambrose O Isah,
Date: 2017-02-01 -
Signals
Lamivudine - Hearing decreased
WHO Pharmaceuticals Newsletter, 2017, No.1, p23.
Author: Ambrose O Isah
Date: 2017-02-01 -
Signals
Ganciclovir - Hypoglycaemia
WHO Pharmaceuticals Newsletter, 2017, No.1, p19.
Author: Richard Day
Date: 2017-02-01 -
Signals
Denosumab - Lichen planus
WHO Pharmaceuticals Newsletter, 2016, No.6, p15.
Author: Ian Boyd
Date: 2016-12-01 -
Signals
Denosumab - Vasculitis
WHO Pharmaceuticals Newsletter, 2016, No.6, p19.
Author: Ian Boyd
Date: 2016-12-01 -
Signals
Etanercept - Ulceration/necrosis
WHO Pharmaceuticals Newsletter, 2016, No.6, p23.
Author: Marilina Castellano
Date: 2016-12-01 -
Signals
Thiamazole – Rhabdomyolysis
WHO Pharmaceuticals Newsletter, 2016, No.4, p17.
Author: Ian Boyd
Date: 2016-11-24 -
Signals
Dimenhydrinate - Erythema multiforme Stevens-Johnson syndrome
WHO Pharmaceuticals Newsletter, 2016, No.5, p18.
Author: Daniele Sartori
Date: 2016-10-01 -
Signals
Febuxostat – Allergic vasculitis
WHO Pharmaceuticals Newsletter, 2016, No.3, p23.
Author: Ian Boyd
Date: 2016-06-01 -
Signals
Levetiracetam – Impaired renal function
WHO Pharmaceuticals Newsletter, 2016, No.2, p18.
Author: Imti Choonara, Kristina Star
Date: 2016-04-01 -
Signals
Benznidazole – Severe skin reactions
WHO Pharmaceuticals Newsletter, 2016, No.2, p24.
Author: Pia Caduff-Janosa
Date: 2016-04-01 -
Signals
Vemurafenib – Atrial fibrillation
WHO Pharmaceuticals Newsletter, 2016, No.1, p17.
Author: Ruth Savage
Date: 2016-01-01 -
Signals
Vemurafenib – Thrombocytopenia
WHO Pharmaceuticals Newsletter, 2015, No.3, p27.
Author: Geraldine Hill
Date: 2015-11-24 -
Signals
Temozolomide - Oesophagitis
WHO Pharmaceuticals Newsletter, 2015, No.5, p19.
Author: Alfonso Carvajal
Date: 2015-10-01 -
Signals
Dextromethorphan – Serious neurological disorders
WHO Pharmaceuticals Newsletter, 2015, No.5, p18.
Author: Lovisa Sandberg, Sarah Watson
Date: 2015-10-01 -
Signals
Atomoxetine – Dystonia
WHO Pharmaceuticals Newsletter, 2015, No.4, p20.
Author: Ian Boyd
Date: 2015-08-01 -
Signals
Vemurafenib – Tumour lysis syndrome
WHO Pharmaceuticals Newsletter, 2015, No.4, p25.
Author: Birgitta Grundmark
Date: 2015-08-01 -
Signals
Prucalopride – Suicidal ideation
WHO Pharmaceuticals Newsletter, 2015, No.3, p22.
Author: Alessio Gasparotto, Rebecca E Chandler,
Date: 2015-06-01 -
Signals
Golimumab – Migraine
WHO Pharmaceuticals Newsletter, 2015, No.2, p27.
Author: Ian Boyd
Date: 2015-05-01 -
Signals
Brentuximab vedotin - Hepatic disorders
WHO Pharmaceuticals Newsletter, 2015, No.2, p17.
Author: Ruth Savage
Date: 2015-05-01 -
Signals
Vemurafenib - Sepsis
WHO Pharmaceuticals Newsletter, 2015, No.2, p32.
Author: Geraldine Hill
Date: 2015-05-01 -
Signals
Desloratadine – QT-prolongation
WHO Pharmaceuticals Newsletter, 2015, No.2, p23.
Author: Sarah Watson
Date: 2015-05-01 -
Signals
Linagliptin – Cardiac failure
WHO Pharmaceuticals Newsletter, 2015, No.1, p20.
Author: Raquel Herrera Comoglio
Date: 2015-02-01 -
Signals
Atomoxetine – Neutropenia
WHO Pharmaceuticals Newsletter, 2015, No.6, p16.
Author: Ian Boyd
Date: 2015-02-01 -
Signals
Hexetidine- Allergic reactions
WHO Pharmaceuticals Newsletter, 2015, No.1, p18.
Author: Pia-Caduff-Janosa
Date: 2015-02-01 -
Signals
Deferasirox – Pancreatitis
WHO Pharmaceuticals Newsletter, 2015, No.6, p20.
Author: Ian Boyd
Date: 2015-02-01 -
Signals
Desloratadine – Aggressive reaction
WHO Pharmaceuticals Newsletter, 2015, No.6, p25.
Author: Lovisa Sandberg
Date: 2015-02-01 -
SignalsDronedarone - ventricular arrhythmia
WHO Pharmaceuticals Newsletter, 2014, No.6, p18.
Author: Mónica Tarapués
Date: 2014-12-05 -
Signals
Dronedarone - vision abnormal
WHO Pharmaceuticals Newsletter, 2014, No.6, p28.
Author: Ian Boyd
Date: 2014-12-05 -
Signals
Agomelatine – thrombocytopenia
WHO Pharmaceuticals Newsletter, 2014, No.6, p13.
Author: Anita Conforti, Ermelinda Viola
Date: 2014-12-05 -
Signals
Febuxostat - cardiac failure
WHO Pharmaceuticals Newsletter, 2014, No.5, p11.
Author: Dr. Richard Day
Date: 2014-11-03 -
Signals
Fingolimod - T-wave inversion
WHO Pharmaceuticals Newsletter, 2014, No.5, p21.
Author: UMC
Date: 2014-11-03 -
Signals
Pamidronic acid - optic neuritis
WHO Pharmaceuticals Newsletter, 2014, No.5, p18.
Author: Ian Boyd
Date: 2014-11-03 -
Signals
Roflumilast - pneumonia
WHO Pharmaceuticals Newsletter, 2014, No.4, p29.
Author: Dr. Tamás Paál
Date: 2014-09-29 -
Signals
Dronedarone – polyneuropathy
WHO Pharmaceuticals Newsletter, 2014, No.4, p19.
Author: UMC
Date: 2014-09-29 -
Signals
Agomelatine - hypotension
WHO Pharmaceuticals Newsletter, 2014, No.4, p13.
Date: 2014-09-29 -
Signals
Finasteride - convulsions
WHO Pharmaceuticals Newsletter, 2014, No.4, p23.
Author: UMC
Date: 2014-09-29 -
Signals
Dronedarone - AV Block
WHO Pharmaceuticals Newsletter, 2014, No.3, p10.
Author: Raquel Herrera Comoglio
Date: 2014-06-23 -
Signals
Ustekinumab - Vasculitis
WHO Pharmaceuticals Newsletter, 2014, No.3, p18.
Date: 2014-06-23 -
Signals
Vemurafenib - renal failure
WHO Pharmaceuticals Newsletter, 2014, No.3, p23.
Author: Ian Boyd
Date: 2014-06-23 -
Signals
Citalopram and ramipiril – hyponatraemia
WHO Pharmaceuticals Newsletter, 2014, No.2, p10.
Author: Staffan Hägg
Date: 2014-05-30 -
Signals
Vemurafenib – pancreatitis
WHO Pharmaceuticals Newsletter, 2014, No.2, p23.
Author: Daniele Sartori
Date: 2014-05-30 -
Signals
Tocilizumab – Psoriasis and aggravated psoriasis
WHO Pharmaceuticals Newsletter, 2014, No.2, p16.
Author: Ruth Savage
Date: 2014-05-30 -
Signals
Combined Ibuprofen and Metamizole treatment - Acute renal failure
WHO Pharmaceuticals Newsletter, 2014, No.2, p13.
Author: Staffan Hägg
Date: 2014-05-30 -
Signals
Roflumilast - pancreatitis
WHO Pharmaceuticals Newsletter, 2014, No.1, p26.
Date: 2014-03-21 -
Signals
Ibuprofen - erectile dysfunction
WHO Pharmaceuticals Newsletter, 2014, No.1, p18.
Author: Alfonso Carvajal
Date: 2014-03-21 -
Signals
Vemurafenib - granulocytopenia
WHO Pharmaceuticals Newsletter, 2014, No.1, p30.
Author: Geraldine Hill, Ronald Meyboom
Date: 2014-03-21